This collaborative presentation with AMD will introduce PCIe fundamentals for networking engineers, including the new features on PCIe 4.0.We will then show DPDK performance when running 200Gb/s Mellanox device using PCIe Gen4 and AMD 2nd Generation EPYC (Rome) CPU.This presentation will also depict peak performance as well as the key advantages of the new architecture that optimizes local and remote NUMA node performance.